Jesolo is two places: the inland town and Lido di Jesolo on the Adriatic. Most beach hotels are on the Lido. Its piazzas split the long shore into stretches you can choose between.
Around Piazza Drago and Piazza Brescia, the bus station, shops and central beach are close together. Evenings are busier at Piazza Mazzini and in the streets west towards Piazza Marina. If sleep matters, ask for a side street.
East of Piazza Milano, the Lido runs on towards Pineta and Cortellazzo. You stay there for the beach, and the central squares are a longer trip. At the western end, Faro is the other beach-first option away from the centre.
Via Bafile runs behind much of the central waterfront. A seafront room saves the walk to the sand. A hotel one or two streets back works too. Check its beach access and parking.
Swimming season is summer. Cycling and lagoon trips are more comfortable once the beach crowds thin out. Venice takes a full day from Jesolo: a bus to Punta Sabbioni and then a boat, or the direct route through Mestre.