Catania’s lava-stone streets run from Piazza del Duomo toward Etna along Via Etnea. Pick the old centre for markets and churches, the station side for rail trips, or the eastern seafront for a coastal stay.
Piazza del Duomo has the elephant fountain, the cathedral and the entrance to the Pescheria fish market. Via Etnea leads north past Piazza Stesicoro and Villa Bellini. These central streets are walkable, but traffic and evening noise change a lot from block to block.
Southwest of the Duomo, Castello Ursino and its museum sit in a quieter part of the old centre. Via Crociferi has baroque churches close to the Roman theatre. A hotel inside the historic core saves journeys. If you arrive with luggage, find out where the taxi can stop.
Around Catania Centrale and Piazza Giovanni XXIII, trains and intercity buses are close. The streets are more functional than those around the Duomo. East toward Ognina the shoreline is rocky. The sandy Playa lies south of the centre, near the airport, and needs a ride from most sightseeing hotels.
Summer afternoons are hot and dry, so keep long walks for morning or evening. Rain is more frequent from autumn into winter. Etna is a separate excursion. Check current access and conditions before you pick a route up the mountain.